Clin Infect Dis. 2009 Feb 1;48(3):365-7.

Should HLA-B*5701 screening be performed in every ethnic group before starting abacavir?

Park WB, Choe PG, Song KH, Lee S, Jang HC, Jeon JH, Park SW, Park MH, Oh MD, Choe KW.

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Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Abstract

Human leukocyte antigen allele (HLA)-B*5701 is associated with abacavir hypersensitivity. However, the carriage rate of HLA-B*5701 has rarely been studied in Asians. In 534 Korean patients with human immunodeficiency virus infection, HLA-B*5701 status was determined by polymerase chain reaction with HLA-B*5701-specific primers. No patients had the HLA-B*5701 allele (95% confidence interval, 0%-0.7%). This explains the paucity of immunologically confirmed cases of abacavir hypersensitivity in Koreans.

PMID:: 19115972; [PubMed - indexed for MEDLINE]

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