MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals

Retrovirology. 2008 Dec 29:5:118. doi: 10.1186/1742-4690-5-118.

Abstract

MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Cohort Studies
  • Gene Expression Regulation
  • HIV Infections / blood*
  • HIV Infections / immunology
  • HIV Seropositivity*
  • HIV-1 / immunology*
  • Humans
  • Leukocytes, Mononuclear / metabolism
  • MicroRNAs / blood*
  • MicroRNAs / metabolism*
  • T-Lymphocytes / metabolism

Substances

  • MicroRNAs