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Spine J. 2009 Jun;9(6):e5-8. doi: 10.1016/j.spinee.2008.11.008. Epub 2008 Dec 27.

Daptomycin for methicillin-resistant Staphylococcus aureus infections of the spine.

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  • 1Department of Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH 45409, USA. steve.burdette@wright.edu

Abstract

BACKGROUND:

Methicillin-resistant Staphylococcus aureus (MRSA) infection is increasingly common. Treatment with vancomycin-based therapy is often unsuccessful. Daptomycin is a relatively new lipopeptide antibiotic with potent activity against MRSA.

PURPOSE:

To describe the successful management of MRSA infection involving the spine.

STUDY DESIGN:

Two case reports of MRSA infection, one involving epidural and lumbar subdural abscesses, the other with osteomyelitis and discitis.

METHODS:

Two cases are described, one with lumbar epidural and subdural abscesses and the other with osteomyelitis and discitis of the spine. Switching from vancomycin to daptomycin plus rifampin-based therapy resulted in patient improvement that allowed discharge from the hospital.

RESULTS:

Both patients recovered fully from their infection.

CONCLUSIONS:

Daptomycin is a safe and effective option for the treatment of MRSA infection involving the spine.

PMID:
19112049
[PubMed - indexed for MEDLINE]
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