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Cancer Cell. 2009 Jan 6;15(1):1-2. doi: 10.1016/j.ccr.2008.12.007.

The metastasis problem gets stickier.

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  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.


The enormity and complexity of cancer genome data present significant challenges in downstream validation of novel oncogenes and tumor suppressors. In this issue of Cancer Cell, Hu et al. evaluate candidate oncogenes in a recurrent amplification in poor-prognosis breast cancers. They identify and validate the prometastatic gene metadherin (MTDH) as a key modulator of endothelial adhesion and chemoresistance.

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