Methods Mol Biol. 2009;506:331-40.

Humanized mouse models to study the human haematopoietic stem cell compartment.

Source

Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK.

Abstract

The ideal way to assess hematopoietic stem cells is to observe their growth in the endogenous microenvironment where they would receive the appropriate signals. With colonies of inbred mice, it is possible to myeloablate recipients and transplant hematopoietic cells from genetically similar mice and observe the growth of primitive hematopoietic cells in their endogenous environment for a significant proportion (10 months) of an organisms lifespan (29 months average). It is not possible to perform these experiments in humans, but xenotransplantation mouse models provide the closest paradigm for the human hematopoietic environment at the present time.

PMID:: 19110636; [PubMed - indexed for MEDLINE]

MeSH Terms

LinkOut - more resources

Full Text Sources

Springer

Medical

Stem Cells - MedlinePlus Health Information

Supplemental Content

Related citations

Review [The immuno-deficient mice transplantion models in study of human hematopoietic stem cells--review]. [Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004]
Review [The immuno-deficient mice transplantion models in study of human hematopoietic stem cells--review].
Hu D, Huang SA. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Dec; 12(6):875-9.
Review Immune-deficient mouse models for analysis of human stem cells. [Biotechniques. 2003]
Review Immune-deficient mouse models for analysis of human stem cells.
Meyerrose TE, Herrbrich P, Hess DA, Nolta JA. Biotechniques. 2003 Dec; 35(6):1262-72.
Review The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice. [Curr Top Microbiol Immunol. 2008]
Review The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice.
Ishikawa F, Saito Y, Yoshida S, Harada M, Shultz LD. Curr Top Microbiol Immunol. 2008; 324:87-94.
Enhanced in vivo motility of human umbilical cord blood hematopoietic stem/progenitor cells introduced via intra-bone marrow injection into xenotransplanted NOD/SCID mouse. [Exp Hematol. 2009]
Enhanced in vivo motility of human umbilical cord blood hematopoietic stem/progenitor cells introduced via intra-bone marrow injection into xenotransplanted NOD/SCID mouse.
Gao J, Li Y, Lu S, Wang M, Yang Z, Yan X, Zheng Y. Exp Hematol. 2009 Aug; 37(8):990-7. Epub 2009 May 27.
Development of functional human immune system with the transplantations of human fetal liver/thymus tissues and expanded hematopoietic stem cells in RAG2-/-gamma(c)-/- MICE. [Transplant Proc. 2009]
Development of functional human immune system with the transplantations of human fetal liver/thymus tissues and expanded hematopoietic stem cells in RAG2-/-gamma(c)-/- MICE.
Joo SY, Choi BK, Kang MJ, Jung DY, Park KS, Park JB, Choi GS, Joh J, Kwon CH, Jung GO, et al. Transplant Proc. 2009 Jun; 41(5):1885-90.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Humanized mouse models to study the human haematopoietic stem cell compartment.
Humanized mouse models to study the human haematopoietic stem cell compartment.
Methods Mol Biol. 2009 ;506:331-40.

PubMed
The impact of copy number variation on local gene expression in mouse hematopoie...
The impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells.
Nat Genet. 2009 Apr ;41(4):430-7. Epub 2009 Mar 8 .

PubMed
Antigen delivery systems for veterinary vaccine development. Viral-vector based ...
Antigen delivery systems for veterinary vaccine development. Viral-vector based delivery systems.
Vaccine. 2008 Dec 2 ;26(51):6508-28.

PubMed
Rosuvastatin induced rhabdomyolysis in a low risk patient: a case report and rev...
Rosuvastatin induced rhabdomyolysis in a low risk patient: a case report and review of the literature.
Curr Clin Pharmacol. 2009 Jan ;4(1):1-3.

PubMed
Formative research of a quick list for an automated self-administered 24-hour di...
Formative research of a quick list for an automated self-administered 24-hour dietary recall.
J Am Diet Assoc. 2007 Jun ;107(6):1002-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Humanized mouse models to study the human haematopoietic stem cell compartment.

Source

Abstract

MeSH Terms

MeSH Terms

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Related citations

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information