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Cell. 2008 Dec 26;135(7):1175-87. doi: 10.1016/j.cell.2008.12.009.

Tracing the retrograde route in protein trafficking.

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  • 1CNRS UMR144, Centre de Recherche, Traffic, Signaling, and Delivery Laboratory, 75248 Paris Cedex 05, France.


Retrograde transport, in which proteins and lipids are shuttled between endosomes and biosynthetic/secretory compartments such as the Golgi apparatus, is crucial for a diverse range of cellular functions. Mechanistic studies that explore the molecular machinery involved in this retrograde trafficking route are shedding light on the functions of transport proteins and are providing fresh insights into possible new therapeutic directions.

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