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Sci Signal. 2008 Dec 23;1(51):pe54. doi: 10.1126/scisignal.151pe54.

Bursting into the nucleus.

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  • 1Stanford University Medical School, Stanford, CA 94305, USA.


An increase in extracellular Ca(2+) induces the nuclear localization of the Crz1 transcription factor and the activation of target genes in yeast. A recent study indicates that nuclear entry occurs in short stochastic bursts that are unsynchronized within the population of cells. The frequency but not the amplitude of the bursts is controlled by Ca(2+). Modulation of the frequency of the burst coordinates aspects of expression of Crz target genes.

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