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Trends Endocrinol Metab. 2009 Apr;20(3):130-8. doi: 10.1016/j.tem.2008.10.004. Epub 2008 Dec 26.

Nampt: linking NAD biology, metabolism and cancer.

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  • 1University of Leipzig, Hospital for Children and Adolescents, Research Laboratory, Oststr. 21-25, 04317 Leipzig, Germany. antje.garten@medizin.uni-leipzig.de

Abstract

Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD) intermediate. Previously identified as a cytokine pre-B-cell colony-enhancing factor and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in several fields, including NAD biology, metabolism and inflammation. As a NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and influences a variety of metabolic and stress responses. Nampt also plays an important part in regulating insulin secretion in pancreatic beta-cells. Nampt seems to have another function as an immunomodulatory cytokine and, therefore, has a role in inflammation. This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer.

PMID:
19109034
[PubMed - indexed for MEDLINE]
PMCID:
PMC2738422
Free PMC Article
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