AIDS Res Hum Retroviruses. 2009 Feb;25(2):229-36.

Genotypic characterization of CRF01_AE env genes derived from human immunodeficiency virus type 1-infected patients residing in central Thailand.

Utachee P, Jinnopat P, Isarangkura-Na-Ayuthaya P, de Silva UC, Nakamura S, Siripanyaphinyo U, Wichukchinda N, Tokunaga K, Yasunaga T, Sawanpanyalert P, Ikuta K, Auwanit W, Kameoka M.

Source

Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Department of Medical Sciences, Ministry of Public Health, Tiwanon Road, Muang, Nonthaburi, Thailand.

Abstract

CRF01_AE is a major subtype of human immunodeficiency virus type 1 (HIV-1) circulating in Southeast Asia, including Thailand. HIV-1 env genes were amplified by polymerase chain reaction from blood samples of HIV-1-infected patients residing in Thailand in 2006, and cloned into the pNL4-3-derived reporter viral construct. Generated envelope protein (Env)-recombinant virus was examined for its infectivity, and then 35 infectious CRF01_AE Env-recombinant viruses were selected. Sequencing analysis revealed that the interclone variation of the deduced amino acid sequences was higher in CRF01_AE env genes isolated in 2006 than in those isolated in the early 1990s, suggesting that env gene variation has been increasing gradually among CRF01_AE viruses prevalent in Thailand. We also examined the characteristics of the deduced amino acid sequences of 35 CRF01_AE env genes. Our results may provide useful information to help in better understanding the genotype of env genes of CRF01_AE viruses currently circulating in Thailand.

PMID:: 19108694; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

env Gene Products, Human Immunodeficiency Virus

Secondary Source ID

GENBANK/EU743757
GENBANK/EU743758
GENBANK/EU743759
GENBANK/EU743760
GENBANK/EU743761
GENBANK/EU743762
GENBANK/EU743763
GENBANK/EU743764
GENBANK/EU743765
GENBANK/EU743766
GENBANK/EU743767
GENBANK/EU743768
GENBANK/EU743769
GENBANK/EU743770
GENBANK/EU743771
GENBANK/EU743772
GENBANK/EU743773
GENBANK/EU743774
GENBANK/EU743775
GENBANK/EU743776
GENBANK/EU743777
GENBANK/EU743778
GENBANK/EU743779
GENBANK/EU743780
GENBANK/EU743781
GENBANK/EU743782
GENBANK/EU743783
GENBANK/EU743784
GENBANK/EU743785
GENBANK/EU743786
GENBANK/EU743787
GENBANK/EU743788
GENBANK/EU743789
GENBANK/EU743790
GENBANK/EU743791
GENBANK/EU743792
GENBANK/EU743793
GENBANK/EU743794

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Cited by 3 PubMed Central articles

Molecular evolution of HIV-1 CRF01_AE Env in Thai patients. [PLoS One. 2011]
Molecular evolution of HIV-1 CRF01_AE Env in Thai patients.
Boonchawalit S, Jullaksorn D, Uttiyoung J, Yowang A, Krathong N, Chautrakul S, Yamashita A, Ikuta K, Roobsoong A, Kanitvittaya S, et al. PLoS One. 2011; 6(11):e27098. Epub 2011 Nov 2.
Phylodynamics of HIV-1 from a phase III AIDS vaccine trial in Bangkok, Thailand. [PLoS One. 2011]
Phylodynamics of HIV-1 from a phase III AIDS vaccine trial in Bangkok, Thailand.
Pérez-Losada M, Jobes DV, Sinangil F, Crandall KA, Arenas M, Posada D, Berman PW. PLoS One. 2011 Mar 10; 6(3):e16902. Epub 2011 Mar 10.
Two N-linked glycosylation sites in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for the CD4 binding domain. [J Virol. 2010]
Two N-linked glycosylation sites in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for the CD4 binding domain.
Utachee P, Nakamura S, Isarangkura-Na-Ayuthaya P, Tokunaga K, Sawanpanyalert P, Ikuta K, Auwanit W, Kameoka M. J Virol. 2010 May; 84(9):4311-20. Epub 2010 Feb 17.

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