Send to

Choose Destination
See comment in PubMed Commons below
Lab Chip. 2009 Jan 21;9(2):286-90. doi: 10.1039/b807106c. Epub 2008 Oct 30.

Augmenting microgel flow via receptor-ligand binding in the constrained geometries of microchannels.

Author information

  • 1Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6.


We investigated the flow dynamics of biotin-conjugated microgel capsules in avidin-conjugated microchannel constrictions. Microgels were prepared using a microfluidic assembly approach. Biotinylated microgels passing through avidin-modified constrictions slowed relative to several control systems. This effect was observed below a critical velocity of the microgels in the channel-at-large. The reduction in microgel velocity in the constriction occurred for several different sizes of microgels and orifices. Soft compliant microgels showed a lower velocity in the constriction relative to rigid microgels with the same concentration of biotin on the surface, due to the ability of the softer microgels to deform in the orifice and maximize their surface area when in contact with the orifice wall.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Write to the Help Desk