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J Am Chem Soc. 2009 Jan 21;131(2):412-3. doi: 10.1021/ja8066308.

Catalytic carbon-carbon sigma bond activation: an intramolecular carbo-acylation reaction with acylquinolines.

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  • 1Department of Chemistry, University of Minnesota-Twin Cities, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA.


Carbon-carbon sigma-bond activation is a contemporary challenge for organometallic chemistry and catalysis. Herein, we disclose a new alkene carboacylation reaction initiated by quinoline-directed, rhodium-catalyzed C-C sigma bond activation. The alkene carboacylation allows for the construction of all-carbon quaternary centers, with a broad substrate scope, providing access to carbocyclic and heterocyclic ring systems in good to excellent yields.

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