A case of benign intraductal papillary mucinous neoplasm of the pancreas containing two major subtypes

Yuichi Sanada; Kazuhiro Yoshida

A case of benign intraductal papillary mucinous neoplasm of the pancreas containing two major subtypes

J Gastrointestin Liver Dis. 2008 Dec;17(4):457-60.

Authors

Yuichi Sanada¹, Kazuhiro Yoshida

Affiliation

¹ Department of Surgery, Saiseikai Kure Hospital, Department of Surgical Oncology, Gifu Graduate Sch. Med, 1-1 Yanagido Gifu 501-1194, Gifu, Japan. ysanadasurg@hotmail.com

PMID: 19104710

Abstract

Here we report a case of benign intraductal papillary-mucinous neoplasm (IPMN) of the pancreas containing two major subtypes. A 73-year-old man underwent pancreatoduodenectomy for a cystic mass, 5.0 cm in diameter. Histopathologic examinations revealed that IPMN was composed of gastric-type adenoma and intestinal-type borderline lesion. Marked intraluminal nodular growth was observed in the center of the tumor composed of intestinal-type cells positive for MUC2. Our observations suggest that gastric-type epithelium is a precursor of intestinal-type lesions in the stepwise progression of IPMN.

Publication types

Case Reports

MeSH terms

Adenocarcinoma, Mucinous / diagnosis*
Adenocarcinoma, Mucinous / pathology
Adenocarcinoma, Mucinous / surgery
Aged
Carcinoma, Pancreatic Ductal / diagnosis*
Carcinoma, Pancreatic Ductal / pathology
Carcinoma, Pancreatic Ductal / surgery
Carcinoma, Papillary / diagnosis*
Carcinoma, Papillary / pathology
Carcinoma, Papillary / surgery
Cholangiopancreatography, Endoscopic Retrograde
Humans
Male
Mixed Tumor, Malignant / diagnosis*
Mixed Tumor, Malignant / pathology
Mixed Tumor, Malignant / surgery
Mucin-2 / metabolism
Pancreatic Neoplasms / diagnosis*
Pancreatic Neoplasms / pathology
Pancreatic Neoplasms / surgery
Pancreaticoduodenectomy
Tomography, X-Ray Computed

Substances

Mucin-2