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Nat Rev Genet. 2009 Feb;10(2):77-82. doi: 10.1038/nrg2507. Epub 2008 Dec 23.

Prostate cancer genomics: towards a new understanding.

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  • 1Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Room S965, San Francisco, California 94143-0794, USA.


Recent genetics and genomics studies of prostate cancer have helped to clarify the genetic basis of this common but complex disease. Genome-wide studies have detected numerous variants associated with disease as well as common gene fusions and expression 'signatures' in prostate tumours. On the basis of these results, some advocate gene-based individualized screening for prostate cancer, although such testing might only be worthwhile to distinguish disease aggressiveness. Lessons learned from these studies provide strategies for further deciphering the genetic causes of prostate cancer and other diseases.

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