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    Antimicrob Agents Chemother. 2009 Mar;53(3):1252-5. Epub 2008 Dec 22.

    Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools.

    Lynx MD, LaClair DD, McKee EE.

    Source

    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.

    Abstract

    To test whether zidovudine (3'-azido-3'-deoxythymidine) (AZT) inhibition of thymidine phosphorylation causes depletion of the TTP pool resulting in mitochondrial DNA depletion, 3T3-F442a cells were differentiated in the presence of AZT and analyzed to determine mitochondrial DNA content and deoxynucleotide levels. These results suggest that AZT toxicity may not be related to deoxynucleotide pool alterations.

    PMID:
    19104011
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2650558
    Free PMC Article

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