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Trends Genet. 2009 Feb;25(2):63-6. doi: 10.1016/j.tig.2008.11.005. Epub 2008 Dec 26.

Methylation and deamination of CpGs generate p53-binding sites on a genomic scale.

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  • 1Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestrasse 73, D-14195 Berlin, Germany. zemojtel@molgen.mpg.de


The formation of transcription-factor-binding sites is an important evolutionary process. Here, we show that methylation and deamination of CpG dinucleotides generate in vivo p53-binding sites in numerous Alu elements and in non-repetitive DNA in a species-specific manner. In light of this, we propose that the deamination of methylated CpGs constitutes a universal mechanism for de novo generation of various transcription-factor-binding sites in Alus.

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