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Immunity. 2008 Dec 19;29(6):839-41. doi: 10.1016/j.immuni.2008.12.005.

Alternative splicing of CD45: the tip of the iceberg.

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  • 1Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA.


Mechanisms underlying the regulated splicing of CD45 RNA have been long-standing puzzles. In this issue of Immunity, Wu et al. (2008) identify hnRNPLL as a critical regulator of both signal-induced exon skipping in CD45 and global alternative-transcript expression in memory T cells.

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