Semin Hematol. 2009 Jan;46(1):16-23.

New genetic abnormalities and treatment response in acute lymphoblastic leukemia.

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Department of Pediatric Oncology/Hematology, Erasmus Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, The Netherlands.

Abstract

Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.

PMID:: 19100364; [PubMed - indexed for MEDLINE]

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