Send to

Choose Destination
See comment in PubMed Commons below
Arch Pharm Res. 2008 Dec;31(12):1559-63. doi: 10.1007/s12272-001-2151-9. Epub 2008 Dec 20.

Concise synthesis of Obovatol: Chemoselective ortho-bromination of phenol and survey of Cu-catalyzed diaryl ether couplings.

Author information

  • 1College of Pharmacy, CBITRC, Chungbuk National University, Cheongju, 361-763, Korea.


Concise total synthesis of obovatol (1) was achieved from the commercially available eugenol (5) via linear 4 steps in 40% overall yield. The key features of the synthesis involve the chemoselective orthobromination of phenol in the presence of isolated double bond and the efficient Cu-catalyzed Ullmann coupling of two aromatic moieties for the diaryl ether skeleton.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk