Faculty of Kinesiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. hepple@ucalgary.ca
Abstract
The mechanisms by which caloric restriction preserves skeletal muscle health with aging continue to be explored; however, mounting evidence points toward a convergence of effects at the level of the mitochondrion. Specifically, caloric restriction reduces mitochondrial reactive oxygen species production and promotes mitochondrial renewal via enhanced drive on mitochondrial biogenesis and autophagy.