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Exerc Sport Sci Rev. 2009 Jan;37(1):23-8. doi: 10.1097/JES.0b013e3181877dc5.

Why eating less keeps mitochondria working in aged skeletal muscle.

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  • 1Faculty of Kinesiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.


The mechanisms by which caloric restriction preserves skeletal muscle health with aging continue to be explored; however, mounting evidence points toward a convergence of effects at the level of the mitochondrion. Specifically, caloric restriction reduces mitochondrial reactive oxygen species production and promotes mitochondrial renewal via enhanced drive on mitochondrial biogenesis and autophagy.

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