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AIDS. 2009 Jan 14;23(2):257-9. doi: 10.1097/QAD.0b013e328314e382.

Urinary cystatin C can improve the renal safety follow-up of tenofovir-treated patients.

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  • 1CHU Rangueil, Department of Clinical Physiology and Université Toulouse III Paul Sabatier, Toulouse, France.


A receiver operating curve analysis was performed to assess the predictive value of the urinary cystatin C to urinary creatinine ratio for the renal monitoring of tenofovir. Urinary cystatin C to urinary creatinine ratio was measured in 37 samples from patients referred for suspected tenofovir-induced Fanconi syndrome. The best threshold (14 microg/mmol) was associated with sensitivity, 90.9%; specificity, 88.5%; positive predictive value, 76.9%; and negative predictive value, 95.8%. Urinary cystatin C to urinary creatinine ratio allows to rule out a Fanconi syndrome in most cases; thus, it should be used for the safety follow-up of nucleotide reverse transcriptase inhibitor-treated patients.

[PubMed - indexed for MEDLINE]
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