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    Bioorg Med Chem Lett. 2009 Feb 1;19(3):1018-21. Epub 2008 Nov 18.

    Discovery of thiophene inhibitors of polo-like kinase.

    Source

    Oncology R & D, GlaxoSmithKline, Five Moore Drive, PO Box 13398, Research Triangle Park, NC 27709, USA. kyle.a.emmitte@Vanderbilt.edu

    Abstract

    The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.

    PMID:
    19097784
    [PubMed - indexed for MEDLINE]

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