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J Lipid Res. 2009 Apr;50 Suppl:S423-8. doi: 10.1194/jlr.R800094-JLR200. Epub 2008 Dec 17.

Prostanoids in health and disease.

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  • 1Institute for Translational Medicine and Therapeutics, University of Pennsylvania, PA 19104, USA.


The prostanoids are a family of lipid mediators generated by the action of cyclooxygenase on a 20-carbon unsaturated fatty acid, arachidonic acid. Prostanoids are generated widely in response to diverse stimuli and, acting in a paracrine or autocrine manner, play important roles in normal physiology and disease. This review summarizes the current knowledge on prostanoid generation and the roles of individual mediators, their biosynthetic pathways, and their receptors in health and disease.

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