Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Vaccine. 2009 Feb 11;27(7):1050-4. doi: 10.1016/j.vaccine.2008.11.100. Epub 2008 Dec 16.

Reduced reaction frequencies with repeated inactivated or live-attenuated influenza vaccination.

Author information

  • 1University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.

Abstract

Data collected as part of a multi-year trial examining the efficacies of inactivated and live-attenuated influenza vaccines were used to evaluate the reported occurrence of post-vaccination reactions. Two cohorts were defined: (1) individuals who received the same vaccine over two consecutive years, and (2) individuals who first enrolled in year 2 of the study and received vaccine only in that year. For both vaccines there were significantly fewer reactions reported in year 2 in those subjects who were vaccinated both years. Declines were demonstrated when comparing year 1 and 2 reaction frequencies in subjects vaccinated both years, and differences were seen when comparing year 2 reaction frequencies in subjects vaccinated both years with those first vaccinated in year 2. Reaction reporting peaked on post-vaccination days 0 and 1 following receipt of the inactivated vaccine, and on day 2 following receipt of the live-attenuated vaccine.

PMID:
19095028
[PubMed - indexed for MEDLINE]
PMCID:
PMC2665993
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1
Figure 2
Figure 3
Figure 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk