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Vaccine. 2009 Feb 11;27(7):1050-4. doi: 10.1016/j.vaccine.2008.11.100. Epub 2008 Dec 16.

Reduced reaction frequencies with repeated inactivated or live-attenuated influenza vaccination.

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  • 1University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.


Data collected as part of a multi-year trial examining the efficacies of inactivated and live-attenuated influenza vaccines were used to evaluate the reported occurrence of post-vaccination reactions. Two cohorts were defined: (1) individuals who received the same vaccine over two consecutive years, and (2) individuals who first enrolled in year 2 of the study and received vaccine only in that year. For both vaccines there were significantly fewer reactions reported in year 2 in those subjects who were vaccinated both years. Declines were demonstrated when comparing year 1 and 2 reaction frequencies in subjects vaccinated both years, and differences were seen when comparing year 2 reaction frequencies in subjects vaccinated both years with those first vaccinated in year 2. Reaction reporting peaked on post-vaccination days 0 and 1 following receipt of the inactivated vaccine, and on day 2 following receipt of the live-attenuated vaccine.

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