Nat Rev Genet. 2009 Jan;10(1):43-55.

Detecting shared pathogenesis from the shared genetics of immune-related diseases.

Zhernakova A, van Diemen CC, Wijmenga C.

Source

Department of Medical Genetics, University Medical Centre Utrecht, Utrecht 3508 AB, the Netherlands.

Abstract

Recent genetic studies have revealed shared immunological mechanisms in several immune-related disorders that further our understanding of the development and concomitance of these diseases. Our Review focuses on these shared aspects, using the novel findings of recently performed genome-wide association studies and non-synonymous SNP scans as a starting point. We discuss how identifying new genes that are associated with more than one autoimmune or chronic inflammatory disorder could explain the genetic basis of the shared pathogenesis of immune-related diseases. This analysis helps to highlight the key molecular pathways that are involved in these disorders and the potential roles of novel genes in immune-related diseases.

PMID:: 19092835; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Autoimmune Diseases - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. [Nature. 2010]
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, et al. Nature. 2010 Jul 1; 466(7302):113-7.
Review Genetic background of systemic sclerosis: autoimmune genes take centre stage. [Rheumatology (Oxford). 2010]
Review Genetic background of systemic sclerosis: autoimmune genes take centre stage.
Allanore Y, Dieude P, Boileau C. Rheumatology (Oxford). 2010 Feb; 49(2):203-10. Epub 2009 Nov 18.
Review Autoimmunity risk alleles in costimulation pathways. [Immunol Rev. 2009]
Review Autoimmunity risk alleles in costimulation pathways.
Maier LM, Hafler DA. Immunol Rev. 2009 May; 229(1):322-36.
Review The genetics of human autoimmune disease. [J Autoimmun. 2009]
Review The genetics of human autoimmune disease.
Invernizzi P, Gershwin ME. J Autoimmun. 2009 Nov-Dec; 33(3-4):290-9. Epub 2009 Aug 13.
Review Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history. [Expert Rev Gastroenterol Hepat...]
Review Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history.
Lees CW, Satsangi J. Expert Rev Gastroenterol Hepatol. 2009 Oct; 3(5):513-34.

See reviews... See all...

Cited by 32 PubMed Central articles

Review Abundant pleiotropy in human complex diseases and traits. [Am J Hum Genet. 2011]
Review Abundant pleiotropy in human complex diseases and traits.
Sivakumaran S, Agakov F, Theodoratou E, Prendergast JG, Zgaga L, Manolio T, Rudan I, McKeigue P, Wilson JF, Campbell H. Am J Hum Genet. 2011 Nov 11; 89(5):607-18.
A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis. [PLoS One. 2011]
A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.
Nakaoka H, Cui T, Tajima A, Oka A, Mitsunaga S, Kashiwase K, Homma Y, Sato S, Suzuki Y, Inoko H, et al. PLoS One. 2011; 6(9):e25389. Epub 2011 Sep 28.
Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells. [PLoS One. 2011]
Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells.
Clark JM, Aleksiyadis K, Martin A, McNamee K, Tharmalingam T, Williams RO, Mémet S, Cope AP. PLoS One. 2011; 6(9):e24504. Epub 2011 Sep 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Detecting shared pathogenesis from the shared genetics of immune-related disease...
Detecting shared pathogenesis from the shared genetics of immune-related diseases.
Nat Rev Genet. 2009 Jan ;10(1):43-55.

PubMed
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activit...
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
Nature. 2009 Jan 1 ;457(7225):57-62. Epub 2008 Dec 17 .

PubMed
Which questions remain unanswered following the successful development of sorafe...
Which questions remain unanswered following the successful development of sorafenib in hepatocellular carcinoma?
Nat Clin Pract Oncol. 2009 Feb ;6(2):64-5. Epub 2008 Dec 17 .

PubMed
Neuroelectric signatures of reward learning and decision-making in the human nuc...
Neuroelectric signatures of reward learning and decision-making in the human nucleus accumbens.
Neuropsychopharmacology. 2009 Jun ;34(7):1649-58. Epub 2008 Dec 17 .

PubMed
The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional a...
The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P.
Eur J Hum Genet. 2009 Jun ;17(6):774-84. Epub 2008 Dec 17 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Detecting shared pathogenesis from the shared genetics of immune-related diseases.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 32 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information