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J Biol Chem. 2009 Apr 24;284(17):11001-5. doi: 10.1074/jbc.R800073200. Epub 2008 Dec 17.

Rassf family of tumor suppressor polypeptides.

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  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. avruch@molbio.mgh.harvard.edu


The Rassf1-6 polypeptides each contain a Ras/Rap association domain, which enables binding to several GTP-charged Ras-like GTPases, at least in vitro or when overexpressed. The Ras/Rap association domains are followed by SARAH domains, which mediate Rassf heterodimerization with the Mst1/2 protein kinases. Rassf1A is unequivocally a tumor suppressor, and all Rassf proteins behave like tumor suppressors, exhibiting epigenetic silencing of expression in many human cancers and pro-apoptotic and/or anti-proliferative effects when re-expressed in tumor cell lines. Herein, we review the binding of the Rassf polypeptides to Ras-like GTPases and the Mst1/2 kinases and their role in Rassf function.

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