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J Infect. 2009 Jan;58(1):68-75. doi: 10.1016/j.jinf.2008.11.008. Epub 2008 Dec 16.

Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever.

Author information

  • 1Research Institute for Internal Medicine, Rikshospitalet University Hospital, 0027 Oslo, Norway. jan.k.damas@ntnu.no

Abstract

OBJECTIVES:

Mediterranean spotted fever (MSF) caused by Rickettsia conorii (R. conorii) is a potential lethal disease while African tick bite fever (ATBF) caused by Rickettsia africae is a self-limiting flu-like illness. We hypothesized that different inflammatory potential in endothelial cells could contribute to the different clinical features in these rickettsioses.

METHODS:

We analyzed the effect of heat-inactivated R. africae and R. conorii on the mRNA and protein levels of monocyte chemoattractant protein (MCP)-1, interleukin (IL)-8 and adhesion molecules in endothelial cells. Serum samples from patients with MSF (n=16) and ATBF (n=15) were collected before and after therapy.

RESULTS:

R. conorii induced a marked increase in MCP-1, IL-8, and adhesion molecules in endothelial cells, involving toll-like receptor 4 activation. In contrast, R. africae induced MCP-1 expression, but only modest or no responses were seen on IL-8 and adhesion molecules. Comparable to the in vitro response, levels of IL-8 and adhesion molecules showed no or only a modest increase in ATBF patients while these inflammatory markers were markedly elevated during MSF.

CONCLUSIONS:

Our findings suggest a superior inflammatory potential of R. conorii as compared to R. africae in endothelial cells, potentially related to the more severe inflammation in MSF comparing ATBF.

PMID:
19091423
[PubMed - indexed for MEDLINE]
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