Pharmacol Ther. 2009 Mar;121(3):253-64. Epub 2008 Nov 27.

Pharmacotherapy for adults with tumors of the central nervous system.

Source

Departments of Pediatrics, Neurology, and Neurobiology & Anatomy, University of Rochester Medical Center, Rochester, NY, USA. nina_schor@urmc.rochester.edu

Abstract

Tumors of the adult central nervous system are among the most common and most chemoresistant neoplasms. Malignant tumors of the brain and spinal cord collectively account for approximately 1.3% of all cancers and 2.2% of all cancer-related deaths. Novel pharmacological approaches to nervous system tumors are urgently needed. This review presents the current approaches and challenges to successful pharmacotherapy of adults with malignant tumors of the central nervous system and discusses novel approaches aimed at overcoming these challenges.

PMID:: 19091301; [PubMed - indexed for MEDLINE]
PMCID: PMC2782733

Free PMC Article

Images from this publication.See all images (3) Free text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Related citations

Review New approaches to pharmacotherapy of tumors of the nervous system during childhood and adolescence. [Pharmacol Ther. 2009]
Review New approaches to pharmacotherapy of tumors of the nervous system during childhood and adolescence.
Schor NF. Pharmacol Ther. 2009 Apr; 122(1):44-55. Epub 2009 Jan 23.
Review Insights into pharmacotherapy of malignant glioma in adults. [Expert Opin Pharmacother. 2009]
Review Insights into pharmacotherapy of malignant glioma in adults.
Salvati M, D'Elia A, Formichella AI, Frati A. Expert Opin Pharmacother. 2009 Oct; 10(14):2279-90.
Early-stage progress on glioma vaccines. [J Natl Cancer Inst. 2011]
Early-stage progress on glioma vaccines.
Brower V. J Natl Cancer Inst. 2011 Sep 21; 103(18):1361-2. Epub 2011 Aug 31.
Review Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors. [Cancer. 1989]
Review Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors.
Rodriguez LA, Prados M, Silver P, Levin VA. Cancer. 1989 Dec 15; 64(12):2420-3.
Review Cellular immunity and immunotherapy of brain tumors. [Front Biosci. 2004]
Review Cellular immunity and immunotherapy of brain tumors.
Prins RM, Liau LM. Front Biosci. 2004 Sep 1; 9:3124-36. Epub 2004 Sep 1.

See reviews... See all...

Cited by 3 PubMed Central articles

Overcoming the challenges in the effective delivery of chemotherapies to CNS solid tumors. [Ther Deliv. 2010]
Overcoming the challenges in the effective delivery of chemotherapies to CNS solid tumors.
Sarin H. Ther Deliv. 2010 Aug; 1(2):289-305.
Sensitivity to cisplatin in primary cell lines derived from human glioma correlates with levels of EGR-1 expression. [Cancer Cell Int. 2011]
Sensitivity to cisplatin in primary cell lines derived from human glioma correlates with levels of EGR-1 expression.
Calogero A, Porcellini A, Lombari V, Fabbiano C, Arcella A, Miscusi M, Ponti D, Ragona G. Cancer Cell Int. 2011 Mar 2; 11:5. Epub 2011 Mar 2.
Review Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety. [Curr Gene Ther. 2009]
Review Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety.
Candolfi M, Kroeger KM, Muhammad AK, Yagiz K, Farrokhi C, Pechnick RN, Lowenstein PR, Castro MG. Curr Gene Ther. 2009 Oct; 9(5):409-21.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Pharmacotherapy for adults with tumors of the central nervous system.
Pharmacotherapy for adults with tumors of the central nervous system.
Pharmacol Ther. 2009 Mar ;121(3):253-64. Epub 2008 Nov 27 .

PubMed
Critical review on non-operative management of adolescent idiopathic scoliosis.
Critical review on non-operative management of adolescent idiopathic scoliosis.
Prosthet Orthot Int. 2003 Dec ;27(3):242-53.

PubMed
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. P...
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine.
Bioorg Med Chem. 2008 May 15 ;16(10):5653-64. Epub 2008 Mar 30 .

PubMed
Site- and time-specific gene targeting in the mouse.
Site- and time-specific gene targeting in the mouse.
Methods. 2001 May ;24(1):71-80.

PubMed
Is parity in the eye of the beholder?
Is parity in the eye of the beholder?
Int Urogynecol J Pelvic Floor Dysfunct. 2008 Jun ;19(6):753-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Pharmacotherapy for adults with tumors of the central nervous system.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information