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Appl Environ Microbiol. 2009 Feb;75(4):1197-200. doi: 10.1128/AEM.02351-08. Epub 2008 Dec 16.

L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR.

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  • 1Institute of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany.

Abstract

Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L-valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.

PMID:
19088318
[PubMed - indexed for MEDLINE]
PMCID:
PMC2643581
Free PMC Article
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