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Institut for International Sundhed, Immunologi og Mikrobiologi, Panum Instituttet, Københavns Universitet, bygning 22.5, DK-2200 København N. p.holst@immi.ku.dk
We may expect that the next influenza pandemic will affect about half the world's population within a year and that it will cause unpredictable mortality rates. In this perspective, we review the molecular mechanisms underlying the development of new pandemic influenza strains and a discussion on existing and future vaccination strategies directed towards prevention of pandemic influenza is presented. There is an urgent need to develop paninfluenza-specific vaccines and invest substantially in new technologies in order to better meet this threat.
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