Display Settings:

Format

Send to:

Choose Destination
Exp Clin Psychopharmacol. 2008 Dec;16(6):498-502. doi: 10.1037/a0014190.

Narrowing in on compulsions: dopamine receptor functions.

Author information

  • 1Department of Pharmacology, 1301 Medical Science Research Building III, 1150 W. Medical Center Drive, University of Michigan, Ann Arbor, MI 48109-0632, USA. collinsg@umich.edu

Abstract

A series of experiments in rats explored the possibility that D3/D2 dopamine receptors are involved in behaviors that might be related to compulsion. A series of D3/D2 agonists and antagonists were shown to elicit yawning (D3-receptor mediated) and its inhibition (D2-receptor mediated). In rats with histories of cocaine exposure, D3-agonist-elicited yawning was enhanced, and quinpirole led to persistent operant responding only if conditioned stimuli associated with cocaine were presented for responding. Finally, a more selective D3 partial agonist was reported that had a novel profile of activity that could have relevance to the suppression of dopamine-related compulsions.

(c) 2008 APA, all rights reserved.

PMID:
19086770
[PubMed - indexed for MEDLINE]
PMCID:
PMC3094917
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1
Figure 2
Figure 3
Figure 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Psychological Association Icon for PubMed Central
    Loading ...
    Write to the Help Desk