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Exp Clin Psychopharmacol. 2008 Dec;16(6):498-502. doi: 10.1037/a0014190.

Narrowing in on compulsions: dopamine receptor functions.

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  • 1Department of Pharmacology, 1301 Medical Science Research Building III, 1150 W. Medical Center Drive, University of Michigan, Ann Arbor, MI 48109-0632, USA. collinsg@umich.edu


A series of experiments in rats explored the possibility that D3/D2 dopamine receptors are involved in behaviors that might be related to compulsion. A series of D3/D2 agonists and antagonists were shown to elicit yawning (D3-receptor mediated) and its inhibition (D2-receptor mediated). In rats with histories of cocaine exposure, D3-agonist-elicited yawning was enhanced, and quinpirole led to persistent operant responding only if conditioned stimuli associated with cocaine were presented for responding. Finally, a more selective D3 partial agonist was reported that had a novel profile of activity that could have relevance to the suppression of dopamine-related compulsions.

(c) 2008 APA, all rights reserved.

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