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J Matern Fetal Neonatal Med. 2009 Jan;22(1):13-23. doi: 10.1080/14767050802415728.

Gross placental measures and childhood growth.

Author information

  • 1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. kbrobert@jhsph.edu

Abstract

OBJECTIVES:

We hypothesised that the gross placental measures would be positively associated with childhood growth.

METHODS:

We analysed data on 23,967 mother-infant pairs enrolled in the Collaborative Perinatal Project. In race-stratified regression models, the main outcomes were birthweight and z-score body-mass index (BMI) at ages 4 and 7.

RESULTS:

Some placental measures were significantly associated with z-score BMI at age 7: in Blacks, placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0008), chorionic plate area (beta = 0.0007; 95%CI: 0.0001, 0.0012) and largest diameter (beta = 0.013; 95%CI: 0.004, 0.026); and in Whites placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0003) and largest diameter (Model 3: beta = 0.020; 95%CI: 0.007, 0.032). Tested as group, placental measures significantly predicted z-score BMI at age 7 (all p values < 0.005).

CONCLUSIONS:

Placental structure independently predicts birthweight and childhood growth. Strategies to improve placental structure might favourably influence birthweight and childhood development.

PMID:
19085212
[PubMed - indexed for MEDLINE]
PMCID:
PMC3713228
Free PMC Article
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