Long-term outcomes of nonconditioned patients with severe combined immunodeficiency transplanted with HLA-identical or haploidentical bone marrow depleted of T cells with anti-CD6 mAb

J Allergy Clin Immunol. 2008 Dec;122(6):1185-93. doi: 10.1016/j.jaci.2008.10.030.

Abstract

Background: Between 1981 and 1995, 20 children with severe combined immunodeficiency (SCID; median age at transplant, 6.5 [range, 0.5-145] mo, 12 with serious infection) were treated with haploidentical T cell-depleted (anti-CD6 antibody) bone marrow (median number of 5.7 [0.8-18.8] x 10(8) nucleated cells/kg) from mismatched related donors (MMRDs), and 5 children with SCID (median age at transplant, 1.8 [0.5-5.0] mo, 1 with serious infection) were given unmanipulated bone marrow from matched related donors (MRDs). No conditioning or graft-versus-host disease (GvHD) prophylaxis was used.

Objective: To assess the outcomes of patients with SCID who received bone marrow from MMRDs or MRDs.

Methods: We reviewed the medical records of these 25 consecutive patients with SCID (4 with Omenn syndrome).

Results: Of the 20 patients who received bone marrow from MMRDs, 12 engrafted, 10 survived at a median age of 15.2 [10.0-19.1] years, 4 had chronic GvHD (lung, intestine, skin), 5 required intravenous immunoglobulin, and 8 attended school or college. Two of 5 patients who died had chronic GvHD, and 2 developed lymphoproliferative disease. Of the 5 patients who received bone marrow from MRDs, 5 engrafted, 5 survived at a median age of 23.3 [18.5-26] years, 1 had chronic GvHD (lung, skin), 2 required intravenous immunoglobulin, and 4 attended school or college.

Conclusions: Treatment of critically ill patients with SCID with anti-CD6 antibody T cell-depleted MMRD marrow resulted in an overall 50% long-term survival of patients (83% survival of those engrafted). The principal barriers to long-term survival were delay in diagnosis, life-threatening infection, failure to engraft, and chronic GvHD. Educational goals were achieved in most of the survivors.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Monoclonal / pharmacology*
  • Antigens, CD / pharmacology*
  • Antigens, Differentiation, T-Lymphocyte / pharmacology*
  • Bone Marrow Transplantation*
  • Child
  • Child, Preschool
  • Disease-Free Survival
  • Female
  • Graft Rejection / mortality
  • Graft Survival / drug effects
  • Graft vs Host Disease / mortality
  • Humans
  • Infant
  • Lymphocyte Depletion*
  • Lymphoproliferative Disorders / mortality
  • Male
  • Retrospective Studies
  • Severe Combined Immunodeficiency / mortality*
  • Severe Combined Immunodeficiency / therapy*
  • Survival Rate
  • T-Lymphocytes*
  • Time Factors

Substances

  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • CD6 antigen