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Mol Biosyst. 2008 Oct;4(10):987-92. doi: 10.1039/b719627j. Epub 2008 Jun 30.

Kinetochore assembly: building a molecular machine that drives chromosome movement.

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  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.


Kinetochores play crucial roles in mediating chromosome segregation. Major progress has been made in recent years in identifying their biochemical composition, the assembly patterns and the mechanisms of their functions.

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