Format

Send to:

Choose Destination
See comment in PubMed Commons below
Chem Commun (Camb). 2008 Dec 14;(46):6095-107. doi: 10.1039/b810957e. Epub 2008 Oct 1.

The effects of hydrogen bonds on metal-mediated O2 activation and related processes.

Author information

  • 1Department of Chemistry, University of California-Irvine, 1102 Natural Sciences II, Irvine, California 92697-2025, USA.

Abstract

Hydrogen bonds stabilize and direct chemistry performed by metalloenzymes. With inspiration from enzymes, we will utilize an approach that incorporates intramolecular hydrogen bond donors to determine their effects on the stability and reactivity of metal complexes. Our premise is that control of secondary coordination sphere interactions will promote new function in synthetic metal complexes. Multidentate ligands have been developed that create rigid organic structures around metal ions. These ligands place hydrogen bond (H-bond) donors proximal to the metal centers, forming specific microenvironments. One distinguishing attribute of these systems is that site-specific modulations in structure can be readily accomplished, in order to evaluate correlations with reactivity. A focus of this research is consideration of dioxygen binding and activation by metal complexes, including developing structure-function relationships in metal-assisted oxidative catalysis.

PMID:
19082087
[PubMed - indexed for MEDLINE]
PMCID:
PMC2921322
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry Icon for PubMed Central
    Loading ...
    Write to the Help Desk