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    Ultrastruct Pathol. 1991 May-Jun;15(3):215-9.

    Ultrastructural localization of synaptophysin to the secretory granules of normal glucagon and insulin cells in human islets of Langerhans.

    Kalina M, Lukinius A, Grimelius L, Höög A, Falkmer S.

    Department of Pathology, University of Uppsala, Sweden.

    Immunogold labeling of the pancreatic islets in humans by means of monoclonal antibodies to synaptophysin resulted in a distinct localization of gold particles to the secretory granules of glucagon-immunoreactive cells. The same type of immunoreactivity was noted with antiserum to chromogranin A. Glucagon immunoreactivity was concentrated in the dense central core of the secretory granules. Some immunoreactivity for synaptophysin was also found in the secretory granules of the insulin-producing cells, although it was weaker in this location.

    PMID: 1908157 [PubMed - indexed for MEDLINE]

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    Patient drug information

    • Glucagon (GlucaGen Diagnostic Kit®)

      Glucagon is a hormone produced in the pancreas. Glucagon is used to raise very low blood sugar. Glucagon is also used in diagnostic testing of the stomach and other digestive organs.

    • Source: AHFS Consumer Medication Information

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