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Dev Cell. 2008 Dec;15(6):795-6. doi: 10.1016/j.devcel.2008.11.013.

ER stress and lipogenesis: a slippery slope toward hepatic steatosis.

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  • 1Department of Medicine, McMaster University, St. Joseph's Healthcare and the Henderson Research Centre, Hamilton, ON, Canada.


Endoplasmic reticulum (ER) stress and activation of the unfolded protein response have been linked to many human disorders, including obesity, type 2 diabetes, and cancer. In this issue of Developmental Cell,Rutkowski et al. (2008) show that unresolved ER stress contributes to metabolic dysfunction and hepatic steatosis.

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