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Curr Neurol Neurosci Rep. 2009 Jan;9(1):83-9.

Inclusion body myositis: review of recent literature.

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  • 1Department of Neurology, Brigham and Women's Hospital,75 Francis Street, Boston, MA 02115, USA. sagreenberg@partners.org

Abstract

Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the beta-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regarding treatment.

PMID:
19080758
[PubMed - indexed for MEDLINE]
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