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Mucosal Immunol. 2008 Nov;1 Suppl 1:S10-4. doi: 10.1038/mi.2008.49.

Innate immune recognition of the indigenous microbial flora.

Author information

  • 1Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA. seth.rakoff-nahoum@yale.edu


Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of tissue injury and repair, spontaneous colitis, and postnatal development.

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