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Nature. 2008 Dec 11;456(7223):E5-6. doi: 10.1038/nature07646.

FCA does not bind abscisic acid.

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  • 1Biochemistry Department, University of Otago, Dunedin 9054, New Zealand. catherine.day@otago.ac.nz.


The RNA-binding protein FCA promotes flowering in Arabidopsis. Razem et al. reported that FCA is also a receptor for the phytohormone abscisic acid (ABA). However, we find that FCA does not bind ABA, suggesting that the quality of the proteins assayed and the sensitivity of the ABA-binding assay have led Razem et al. to erroneous conclusions. Because similar assays have been used to characterize other ABA receptors, our results indicate that the ABA-binding properties of these proteins should be carefully re-evaluated and that alternative ABA receptors are likely to be discovered.

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