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Aging Cell. 2009 Feb;8(1):73-5. doi: 10.1111/j.1474-9726.2008.00449.x. Epub 2008 Dec 11.

The overexpression of major antioxidant enzymes does not extend the lifespan of mice.

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  • 1Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 78229, USA.


We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.

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