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    J Biol Chem. 2009 Feb 13;284(7):4383-91. Epub 2008 Dec 15.

    Lack of cytochrome c in mouse fibroblasts disrupts assembly/stability of respiratory complexes I and IV.

    Vempati UD, Han X, Moraes CT.

    Department of Neurology and Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.

    Cytochrome c (cyt c) is a heme-containing protein that participates in electron transport in the respiratory chain and as a signaling molecule in the apoptotic cascade. Here we addressed the effect of removing mammalian cyt c on the integrity of the respiratory complexes in mammalian cells. Mitochondria from cyt c knockout mouse cells lacked fully assembled complexes I and IV and had reduced levels of complex III. A redox-deficient mutant of cyt c was unable to rescue the levels of complexes I and IV. We found that cyt c is associated with both complex IV and respiratory supercomplexes, providing a potential mechanism for the requirement for cyt c in the assembly/stability of complex IV.

    PMID: 19075019 [PubMed - indexed for MEDLINE]

    PMCID: 2640958

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