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Science. 2008 Dec 12;322(5908):1705-10. doi: 10.1126/science.1159894.

Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.

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  • 1INSERM U653, Institut Curie, 12 rue Lhomond, 75005, Paris, France.

Abstract

Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild-type DCs alternate between high and low motility, whereas Ii-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by Ii depended on the actin-based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space.

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PMID:
19074353
[PubMed - indexed for MEDLINE]
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