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Semin Cell Dev Biol. 2009 Apr;20(2):201-10. doi: 10.1016/j.semcdb.2008.11.014. Epub 2008 Nov 27.

Presenilin: RIP and beyond.

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  • 1Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO, United States.

Abstract

Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through gamma-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of beta-catenin function, protein trafficking, calcium regulation, and apoptosis.

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