Send to

Choose Destination
See comment in PubMed Commons below
Semin Cell Dev Biol. 2009 Apr;20(2):201-10. doi: 10.1016/j.semcdb.2008.11.014. Epub 2008 Nov 27.

Presenilin: RIP and beyond.

Author information

  • 1Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO, United States.


Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through gamma-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of beta-catenin function, protein trafficking, calcium regulation, and apoptosis.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk