Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Clin Apher. 2009;24(1):47-52. doi: 10.1002/jca.20182.

Atypical presentations of thrombotic thrombocytopenic purpura: a review.

Author information

  • 1Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9073, USA. ravi.sarode@utsouthwestern.edu

Abstract

Thrombotic thrombocytopenic purpura (TTP) is diagnosed by the presence of microangiopathic hemolytic anemia and thrombocytopenia in a patient who frequently presents with central nervous system involvement and, to a lesser extent, renal dysfunction. Recent understanding of the pathophysiology of TTP due to severe deficiency of von Willebrand factor cleaving protease, known as ADAMTS13, has improved diagnosis of TTP. Once the diagnosis is suspected, life-saving therapeutic plasma exchange therapy is initiated. Occasionally, an unusual clinical presentation makes TTP diagnosis difficult, thus resulting in a delay in the management of TTP. This review highlights a variety of atypical TTP presentations described in the literature. It is intended to bring unusual scenarios to the clinician's awareness, so that timely treatment can be delivered.

(c) 2008 Wiley-Liss, Inc.

PMID:
19073011
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk