Dev Disabil Res Rev. 2008;14(4):261-7.

Cognitive neuroscience of Attention Deficit Hyperactivity Disorder: current status and working hypotheses.

Source

Department of Psychology, Georgetown University, Washington, DC 20057, USA. cjv2@georgetown.edu

Abstract

Cognitive neuroscience studies of Attention Deficit Hyperactivity Disorder (ADHD) suggest multiple loci of pathology with respect to both cognitive domains and neural circuitry. Cognitive deficits extend beyond executive functioning to include spatial, temporal, and lower-level "nonexecutive" functions. Atypical functional anatomy extends beyond frontostriatal circuits to include posterior cortices, limbic regions, and the cerebellum. Pathophysiology includes dopaminergic as well as noradrenergic neurotransmitter systems. We review the major insights gained from functional brain imaging studies in ADHD and discuss working hypotheses regarding their neurochemical underpinnings.

PMID:: 19072750; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

MH65395/MH/NIMH NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Attention Deficit Hyperactivity Disorder - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review [Structural and functional neuroanatomy of attention-deficit hyperactivity disorder (ADHD)]. [Encephale. 2009]
Review [Structural and functional neuroanatomy of attention-deficit hyperactivity disorder (ADHD)].
Emond V, Joyal C, Poissant H. Encephale. 2009 Apr; 35(2):107-14. Epub 2008 Jul 7.
Review Neuroimaging in attention-deficit hyperactivity disorder: beyond the frontostriatal circuitry. [Can J Psychiatry. 2009]
Review Neuroimaging in attention-deficit hyperactivity disorder: beyond the frontostriatal circuitry.
Cherkasova MV, Hechtman L. Can J Psychiatry. 2009 Oct; 54(10):651-64.
White-matter abnormalities in attention deficit hyperactivity disorder: a diffusion tensor imaging study. [Hum Brain Mapp. 2009]
White-matter abnormalities in attention deficit hyperactivity disorder: a diffusion tensor imaging study.
Silk TJ, Vance A, Rinehart N, Bradshaw JL, Cunnington R. Hum Brain Mapp. 2009 Sep; 30(9):2757-65.
Review Using developmental cognitive neuroscience to study behavioral and attentional control. [Dev Psychobiol. 2009]
Review Using developmental cognitive neuroscience to study behavioral and attentional control.
Astle DE, Scerif G. Dev Psychobiol. 2009 Mar; 51(2):107-18.
A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention. [Cortex. 2012]
A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention.
Cubillo A, Halari R, Smith A, Taylor E, Rubia K. Cortex. 2012 Feb; 48(2):194-215. Epub 2011 Apr 27.

See reviews... See all...

Cited by 7 PubMed Central articles

Neurodevelopmental abnormalities in ADHD. [Curr Top Behav Neurosci. 2012]
Neurodevelopmental abnormalities in ADHD.
Vaidya CJ. Curr Top Behav Neurosci. 2012; 9:49-66.
Altered white matter microstructure in children with attention-deficit/hyperactivity disorder. [J Am Acad Child Adolesc Psychi...]
Altered white matter microstructure in children with attention-deficit/hyperactivity disorder.
Nagel BJ, Bathula D, Herting M, Schmitt C, Kroenke CD, Fair D, Nigg JT. J Am Acad Child Adolesc Psychiatry. 2011 Mar; 50(3):283-92. Epub 2011 Jan 20.
Effect of dopamine transporter genotype on caudate volume in childhood ADHD and controls. [Am J Med Genet B Neuropsychiat...]
Effect of dopamine transporter genotype on caudate volume in childhood ADHD and controls.
Shook D, Brady C, Lee PS, Kenealy L, Murphy ER, Gaillard WD, VanMeter JW, Cook EH Jr, Stein M, Vaidya CJ. Am J Med Genet B Neuropsychiatr Genet. 2011 Jan; 156B(1):28-35. Epub 2010 Oct 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cognitive neuroscience of Attention Deficit Hyperactivity Disorder: current stat...
Cognitive neuroscience of Attention Deficit Hyperactivity Disorder: current status and working hypotheses.
Dev Disabil Res Rev. 2008 ;14(4):261-7.

PubMed
The impact of race and ethnicity on receipt of family planning services in the U...
The impact of race and ethnicity on receipt of family planning services in the United States.
J Womens Health (Larchmt). 2009 Jan-Feb ;18(1):91-6.

PubMed
rbcR [correction of rcbR], a gene coding for a member of the LysR family of tran...
rbcR [correction of rcbR], a gene coding for a member of the LysR family of transcriptional regulators, is located upstream of the expressed set of ribulose 1,5-bisphosphate carboxylase/oxygenase genes in the photosynthetic bacterium Chromatium vinosum.
J Bacteriol. 1991 Aug ;173(16):5224-9.

PubMed
Epigenetics and obesity.
Epigenetics and obesity.
Pharmacogenomics. 2008 Dec ;9(12):1851-60.

PubMed
Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, ex...
Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment.
FASEB J. 1991 Jun ;5(9):2304-12.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: