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J Infect Dis. 2009 Jan 15;199(2):196-200. doi: 10.1086/595831.

A newly identified bocavirus species in human stool.

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  • 1Blood Systems Research Institute and Department of Laboratory Medicine, University of California, San Francisco, CA 94118, USA.

Abstract

Viral metagenomic analysis was used to identify a previously uncharacterized parvovirus species, "HBoV2," whose closest phylogenetic relative is the human bocavirus (HBoV). HBoV2 has a genomic organization identical to that of HBoV but has only 78%, 67%, and 80% identity, respectively, with the latter's NS1, NP1, and VP1/VP2 proteins. The study used polymerase chain reaction to detect HBoV2 sequences in 5 of 98 stool samples from Pakistani children and in 3 of 699 stool samples from Edinburgh. Nearly-full-length genome sequencing revealed the presence of 3 HBoV2 genotypes and evidence of recombination between genotypes. Further studies are necessary to identify anatomical sites of HBoV2 replication and potential associations with clinical symptoms or disease.

PMID:
19072716
[PubMed - indexed for MEDLINE]
PMCID:
PMC2678954
Free PMC Article

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