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Curr Opin Pharmacol. 2009 Apr;9(2):102-8. doi: 10.1016/j.coph.2008.11.006. Epub 2008 Dec 13.

Possible novel targets for therapeutic angiogenesis.

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  • 1Division of Experimental Cardiovascular Medicine, Bristol Heart Institute, University of Bristol, Bristol, UK.


An increasing number of studies about the molecular basis of angiogenesis are rapidly disclosing novel signal pathways involved in the blood vessel formation process. This review will focus on bone morphogenic proteins, Hedgehog, Notch, ephrins, neuropilins, neurotrophins and netrins. These recently discovered angiogenesis mediators are involved in vascular development during embryogenesis and, interestingly, they are shared between the nervous and vascular systems. They represent new potential targets in the vasculature and suggest novel therapeutic opportunities.

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