Audiol Neurootol. 2009;14(3):190-7. Epub 2008 Dec 10.

Expression of the osmotically responsive cationic channel TRPV4 in the endolymphatic sac.

Kumagami H, Terakado M, Sainoo Y, Baba A, Fujiyama D, Fukuda T, Takasaki K, Takahashi H.

Source

Department of Otolaryngology, Nagasaki University, Sakamoto 1-7-1, Nagasaki 852-8501, Japan. kumagami@nagasaki-u.ac.jp

Abstract

The immunohistochemical expression pattern and the physiological role of transient receptor potential vanilloid (TRPV) 4 in the endolymphatic sac were investigated. TRPV4 was expressed predominantly in the apical membrane of mitochondria-rich cells, and cell volume regulation by TRPV4 was observed in a tissue culture of the rat endolymphatic sac. TRPV4 was also present in the endolymphatic sacs of patients with vestibular schwannoma and with Ménière's disease. TRPV4 is assumed to play a role as an osmoreceptor in cell and fluid volume regulation in the human endolymphatic sac.

PMID:: 19066426; [PubMed - indexed for MEDLINE]

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