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Acad Radiol. 2009 Jan;16(1):79-87. doi: 10.1016/j.acra.2008.04.024.

A feasibility study on model-based evaluation of kidney perfusion measured by means of FAIR prepared true-FISP arterial spin labeling (ASL) on a 3-T MR scanner.

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  • 1Department of Angiology, Institute for Diagnostic and Interventional Neuroradiology, University Hospital Berne and University of Berne, Berne, Switzerland. claus.kiefer@insel.ch

Abstract

RATIONALE AND OBJECTIVES:

A feasibility study on measuring kidney perfusion by a contrast-free magnetic resonance (MR) imaging technique is presented.

MATERIALS AND METHODS:

A flow-sensitive alternating inversion recovery (FAIR) prepared true fast imaging with steady-state precession (TrueFISP) arterial spin labeling sequence was used on a 3.0-T MR-scanner. The basis for quantification is a two-compartment exchange model proposed by Parkes that corrects for diverse assumptions in single-compartment standard models.

RESULTS:

Eleven healthy volunteers (mean age, 42.3 years; range 24-55) were examined. The calculated mean renal blood flow values for the exchange model (109 +/- 5 [medulla] and 245 +/- 11 [cortex] ml/min - 100 g) are in good agreement with the literature. Most important, the two-compartment exchange model exhibits a stabilizing effect on the evaluation of perfusion values if the finite permeability of the vessel wall and the venous outflow (fast solution) are considered: the values for the one-compartment standard model were 93 +/- 18 (medulla) and 208 +/- 37 (cortex) ml/min - 100 g.

CONCLUSION:

This improvement will increase the accuracy of contrast-free imaging of kidney perfusion in treatment renovascular disease.

PMID:
19064215
[PubMed - indexed for MEDLINE]
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