Carbohydr Res. 2009 Sep 28;344(14):1788-91. Epub 2008 Sep 26.

Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.

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Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA.

Abstract

In this minireview, we examine the ability of modified citrus pectin (MCP), a complex water soluble indigestible polysaccharide obtained from the peel and pulp of citrus fruits and modified by means of high pH and temperature treatment, to affect numerous rate-limiting steps in cancer metastasis. The anti-adhesive properties of MCP as well as its potential for increasing apoptotic responses of tumor cells to chemotherapy by inhibiting galectin-3 anti-apoptotic function are discussed in the light of a potential use of this carbohydrate-based substance in the treatment of multiple human malignancies.

PMID:: 19061992; [PubMed - indexed for MEDLINE]
PMCID: PMC2782490

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pectin

MW: 194.13 g/mol

MF: C₆H₁₀O₇

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Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.
Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.
Carbohydr Res. 2009 Sep 28 ;344(14):1788-91. Epub 2008 Sep 26 .

PubMed
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Enhancement in fecal excretion of dioxin isomer in mice by several dietary fibers.
Chemosphere. 2001 Oct ;45(2):195-200.

PubMed
Effects of daily oral administration of quercetin chalcone and modified citrus p...
Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon-25 tumor growth in Balb-c mice.
Altern Med Rev. 2000 Dec ;5(6):546-52.

PubMed
Inhibition of spontaneous metastasis in a rat prostate cancer model by oral admi...
Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin.
J Natl Cancer Inst. 1995 Mar 1 ;87(5):348-53.

PubMed
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Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.

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